IN VITRO ANTI -INFLAMMATORY ACTIVITY OF SYRINGIC ACID
By: Chanda, Shilpee
.
Contributor(s): Juvekar, Archana R.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(2).Description: 71-73p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The present study was carried out to investigate
the
in vitro
anti
-inflammatory
activity of syringic acid (SA).
Method
s:
SA was tested for
it's
in
vitro
anti
-inflammatory activity
at different concentrations
in protein denaturation, proteinase inhibition
and
human red blood cell (HRBC)
membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium.
Result
s:
SA
showed
concentration
-dependent inhibition of protein denaturation and proteinase activity with a
half
-maximal
inhibitory
concentration (
IC
50
) value of 49.38
±0.56
μg
/ml
and 53.73
±0.27
μg
/ml
respectively. Heat-
induced
haemolysis
was inhibited by SA with
an IC
50
value
of
57.13
±0. 24
μg
/ml
. SA
also
inhibit
ed
the hypotonicity
-induced
haemolysis
(IC
50
Conclusio
n:
From the present study, we can conclude that SA possesses appreciable anti
-inflammatory
effect against denaturation of proteins,
proteinase activity
, and
human red blood membrane stabilization assays. Further studies are required for determining the possible mechanisms
behind its anti
-inflammatory action.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020891 |
Objective:
The present study was carried out to investigate
the
in vitro
anti
-inflammatory
activity of syringic acid (SA).
Method
s:
SA was tested for
it's
in
vitro
anti
-inflammatory activity
at different concentrations
in protein denaturation, proteinase inhibition
and
human red blood cell (HRBC)
membrane stabilization assay. The reference drugs used were aspirin and diclofenac sodium.
Result
s:
SA
showed
concentration
-dependent inhibition of protein denaturation and proteinase activity with a
half
-maximal
inhibitory
concentration (
IC
50
) value of 49.38
±0.56
μg
/ml
and 53.73
±0.27
μg
/ml
respectively. Heat-
induced
haemolysis
was inhibited by SA with
an IC
50
value
of
57.13
±0. 24
μg
/ml
. SA
also
inhibit
ed
the hypotonicity
-induced
haemolysis
(IC
50
Conclusio
n:
From the present study, we can conclude that SA possesses appreciable anti
-inflammatory
effect against denaturation of proteins,
proteinase activity
, and
human red blood membrane stabilization assays. Further studies are required for determining the possible mechanisms
behind its anti
-inflammatory action.
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